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Creamy Spinach Artichoke Chicken Casserole Recipe

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4.2 from 5 reviews

This creamy spinach artichoke chicken casserole combines tender cooked chicken with flavorful spinach and artichokes all enveloped in a rich, cheesy sauce. Topped with melted mozzarella and Parmesan, it’s an easy, comforting oven-baked dish perfect for a hearty family dinner.

  • Total Time: 45 minutes
  • Yield: 6 servings

Ingredients

Creamy Base

  • 8 ounces cream cheese (at room temperature)
  • 1 cup plain Greek yogurt (or sour cream)
  • 1 cup shredded mozzarella cheese, divided
  • ⅓ cup grated Parmesan cheese, plus more for topping
  • 1 clove garlic, minced
  • ½ teaspoon kosher salt
  • ¼ teaspoon freshly cracked black pepper

Vegetables & Protein

  • 3 cups artichoke hearts, roughly chopped, frozen and defrosted, or canned and drained
  • 1 (5-ounce) bag baby spinach
  • 2 heaping cups cooked chicken

Instructions

  1. Preheat the oven: Heat the oven to 375°F to prepare for baking the casserole.
  2. Mix creamy ingredients: In the bowl of a stand mixer fitted with a paddle attachment, beat together the cream cheese, Greek yogurt, ½ cup shredded mozzarella, Parmesan cheese, minced garlic, kosher salt, and black pepper until the mixture is smooth and well combined. If you don’t have a stand mixer, you can use a hand mixer or mix by hand with a wooden spoon if the cream cheese is fully softened.
  3. Add vegetables and chicken: To the creamy mixture, fold in the chopped artichoke hearts, baby spinach, and cooked chicken, stirring gently by hand to incorporate all ingredients evenly.
  4. Prepare baking dish and assemble: Spray a 9×13-inch ceramic baking dish with avocado oil or cooking spray. Transfer the creamy chicken mixture to the dish and smooth into an even layer. Sprinkle the remaining ½ cup mozzarella and 2 tablespoons Parmesan cheese evenly over the top.
  5. Bake covered: Cover the casserole with foil and bake in the preheated oven for 20 minutes to let the ingredients meld and heat through.
  6. Bake uncovered to brown: Remove the foil and bake for an additional 5 to 10 minutes, or until the top is golden brown and bubbling hot.
  7. Cool and serve: Let the casserole cool for 10 to 15 minutes after baking for easier, cleaner slicing. Serve warm as a comforting and cheesy family meal.

Notes

  • For best mixing results, ensure the cream cheese is fully softened to room temperature.
  • You can substitute sour cream for Greek yogurt if preferred for a tangier flavor.
  • Use cooked chicken from rotisserie, leftover, or freshly poached chicken breasts.
  • Frozen artichoke hearts should be defrosted and drained to prevent excess moisture.
  • Allowing the casserole to rest before serving helps it set for cleaner portioning.
  • This casserole can be made ahead and refrigerated before baking; just increase baking time slightly when cooking from cold.
  • Author: Maya
  • Prep Time: 15 minutes
  • Cook Time: 30 minutes
  • Category: Casserole
  • Method: Baking
  • Cuisine: American
  • Diet: Low Fat