Creamy Cajun Salmon Pasta

Creamy Cajun Salmon Pasta is a bold, indulgent dish that combines perfectly seasoned salmon fillets with tender fettuccine tossed in a rich, spicy parmesan cream sauce. With garlic, sautéed onions, and wilted spinach layered into every bite, this one-pan meal is ready in just 20 minutes—making it ideal for a cozy weeknight dinner that feels restaurant-worthy.

Why You’ll Love This Recipe

This dish delivers the best of both worlds: comfort food and elevated flavor. The Cajun-seasoned salmon adds a smoky, peppery kick that pairs beautifully with the creamy pasta. It’s quick to make, easy to clean up thanks to the one-pan method, and adaptable to your favorite ingredients. Whether you’re feeding family or impressing dinner guests, this pasta is a satisfying crowd-pleaser.

Ingredients

(Tip: You’ll find the full list of ingredients and measurements in the recipe card below.)

12 oz fresh fettuccine pasta (or 8 oz dried)
2 teaspoons olive oil
2 tablespoons unsalted butter, divided
4 salmon fillets (6 oz each)
1/2 onion, minced
2 garlic cloves, minced
1 cup heavy cream
1 cup chicken broth
3 tablespoons Cajun seasoning, divided
1/2 cup grated parmesan cheese
1 cup packed spinach
Salt and pepper, to taste

Directions

1. Cook the pasta in salted water until al dente. Drain and set aside.

2. In a large skillet over medium heat, heat olive oil and 1 tablespoon of butter.

3. Pat the salmon dry, coat with 1 tablespoon of Cajun seasoning, and place fillets skin-side down in the pan.

4. Cook for 3–4 minutes per side, or until the internal temperature reaches 145°F and the salmon flakes easily. Remove and set aside.

5. In the same pan, add the remaining tablespoon of butter and sauté the minced onions for about 2 minutes until soft.

6. Add garlic and cook for another 1 minute until fragrant.

7. Pour in the heavy cream and chicken broth, stirring to combine.

8. Add the remaining 2 tablespoons of Cajun seasoning and parmesan cheese. Simmer for 3–5 minutes until slightly thickened.

9. Add spinach and cooked pasta to the skillet, stirring gently until the spinach wilts and everything is coated in the sauce.

10. Return the salmon to the pan, placing it over the pasta.

11. Let everything sit off heat for 5 minutes to allow the sauce to thicken before serving. Add more parmesan if desired.

Servings and timing

Servings: 4
Prep Time: 5 minutes
Cooking Time: 15 minutes
Total Time: 20 minutes
Calories: Approximately 678 kcal per serving

Variations

• Different Pasta: Swap fettuccine for penne, linguine, or spaghetti.

• Low-Carb Option: Use zucchini noodles or shirataki noodles in place of pasta.

• Add Veggies: Toss in mushrooms, cherry tomatoes, or bell peppers for added texture.

• Lighter Version: Substitute half-and-half or evaporated milk for heavy cream.

• Seafood Mix: Combine salmon with shrimp or scallops for a seafood medley.

• Cheese Swap: Try pecorino or asiago instead of parmesan for a different flavor.

• Extra Heat: Add crushed red pepper flakes or a dash of hot sauce for spicier results.

• Herb Finish: Top with chopped parsley or basil for a fresh touch.

• Dairy-Free: Use a dairy-free cream alternative and vegan cheese to make it dairy-free.

• Grilled Salmon: Grill the salmon separately for a smokier flavor and firmer texture.

Storage/Reheating

Store leftovers in an airtight container in the refrigerator for up to 3 days. Reheat gently on the stovetop over medium-low heat, adding a splash of cream or broth to loosen the sauce. You can also microwave in short bursts, stirring in between. Freezing is not recommended due to the creamy sauce, which may separate upon thawing.

FAQs

Can I use frozen salmon fillets?

Yes, just thaw them completely before seasoning and cooking to ensure even texture and flavor.

What is Cajun seasoning made of?

It typically includes paprika, cayenne, garlic powder, onion powder, oregano, thyme, and black pepper. You can use store-bought or make your own.

Is this dish very spicy?

It has a mild to medium heat. Adjust the Cajun seasoning to taste if you prefer it milder or spicier.

Can I substitute the cream?

Yes, half-and-half or even whole milk can be used, though the sauce may be slightly less thick and rich.

Can I make this dish ahead of time?

You can cook the pasta and salmon in advance, then quickly reheat and combine with the sauce before serving.

How do I know when salmon is done?

The salmon should flake easily with a fork and reach an internal temperature of 145°F.

Can I use a different protein?

Yes, shrimp, chicken, or tofu all make great alternatives to salmon in this dish.

What’s the best type of pasta to use?

Fettuccine works great, but any pasta that holds sauce well—like linguine, penne, or tagliatelle—will also work.

Does this recipe work with gluten-free pasta?

Yes, just cook according to package instructions and avoid overcooking, as gluten-free pasta can get mushy.

Can I skip the spinach?

Of course. You can omit it or replace it with kale, arugula, or another green of your choice.

Conclusion

Creamy Cajun Salmon Pasta is a fast, flavorful, and comforting dish that transforms weeknight dinners into something special. With its rich, spiced cream sauce and tender salmon on a bed of fettuccine, it’s a one-pan meal that doesn’t sacrifice flavor for speed. Perfect for when you want something hearty, delicious, and done in 20 minutes.

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